COVID19: Bat Shit Crazy?

We've Nattered about crowded environments, transmission, seasonal flu numbers, mortality rates, imagined vs real, the backdraft of draconian measures, predicted "superspreader" events, pigs in a poke, monetary policy, preexisting conditions, a lack of global leadership, social habits, cultures, mutation, second hand stupidity, unknown known's, things that seemingly come out of the blue and a collective tabula rasa, all of which have "conspired" in many ways to allow a mischievous Jinn out of it's bottle. Unlike others, this was not to infer that COVID19 is much ado about nothing.  

Alex, I'll take "Things are not what they Seem" for $1000. Trebek: These hanging objects are used to signal the passage of time.


Tonight's offering is of a batty nature, a real wing ding in which one can find fact, humor and juxtaposition that manages to take flight despite a surfeit of MSM guano. Please do enjoy and now picking up where Is It Safe? left off on 05/06...

Bat Shit Crazy. - To be fairly mental, generally used with a bit of confusion.  Extremely irrational or unreasonable, insane, crazy. Presumably from batty (“crazy”) to have bats in one's belfry.
Alex, lets try Orders of Mammals for $800. Trebek: this mammal of the order Chiroptera is the only mammal capable of flight.
We were somewhere around Barstow on the edge of the desert when the drugs began to take hold... And suddenly there was a terrible roar all around us and the sky was full of what looked like huge bats, all swooping and screeching and diving around the car, which was going about a hundred miles an hour with the top down to Las Vegas. - Fear and Loathing In Las Vegas
When flu viruses adapt and grow in the cells of a new host there can be mutations. As a virus proliferates within an individual, its genetic material (RNA) accumulates mutations that are, in turn, passed on to its descendants. 

Alex I'll take pollinators for $500. Trebek queries: Some species of this nocturnal flying creature engage in torpor. 
If the iconoclasts are right, putting coronavirus patients on ventilators could be of little benefit to many and even harmful to some. What’s driving this reassessment is a baffling observation about Covid-19: Many patients have blood oxygen levels so low they should be dead. But they’re not gasping for air, their hearts aren’t racing, and their brains show no signs of blinking off from lack of oxygen. - Ventilators Overused? 
RACE (repeated alveolar collapse and expansion), and VALI (ventilator-associated lung injury) or VILI (ventilator-induced lung injury) comes to mind and upon further review... An oxygen saturation rate below 93% (normal is 95% to 100%) has long been taken as a sign of potential hypoxia, impending organ damage, failure and death. Perhaps somebody changed the rules or "re-combinated" the system lock of late?
A dead host does little to advance a viruses cause, so this may favor the less aggressive variant for prevalence sake, a survival mechanism? Survival of the fittest? - Pig In A Poke?
How did bats become viral reservoirs? Viruses, during evolution, establish a less aggressive relationship with their hosts and bat-virus adaptations have taken millennia. Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. The expression of the viral genome can be regulated, viral gene products can interact, and the genomes of different viruses can recombine to form novel progeny.  Recombination requires simultaneous infection of the same host with different viruses which creates an opportunity to bring together, into a single recombinant virus, multiple mutations that independently confer distinct fitness advantages but that were carried separately in the two parental strains. In any event, recombination  can occur in any species, bat, human etc. ERV's are abundant comprising up to 5–8% of the human genome, thus human DNA has undergone viral modification in the past.

Answering Trebek's 2nd and 3rd queries: What is a bat, that hibernates. As to mystifyingly low oxygen levels invoke Gibb's Rule #39.  Nap time, Moving West...
Si vis pacem, para bellum - Publius Flavius Vegetius Renatus - Parabellum?
Translated, if you want peace prepare for war. Of late, much second hand bat guano has been far flung i.e. bombshell intelligence regarding laboratories, bats, viruses and research of such in China. We read Shi Zhengli's studies long ago, and she is rightfully known and internationally respected as the bat woman.  Shi's studies with Ralph Baric from UNC are seminal and the long term research she has been engaged in, has been ahead of the curve and paramount. To wit...

Bat cave study finds new clues about SARS virus origin... 
In a study received 02/2017, Chinese researchers who spent 5 years analyzing SARS-related viruses in horseshoe bats in a cave in Yunnan province found 11 that had all the genetic building blocks of the strain that infected humans, including 3 that use the same receptor to enter human cells.


To prepare for war follow Lao Tzu's advice: Know yourself, your enemy, your environment and the truth. 

From a pandemic threat standpoint, Zhengli and researchers like her "get it" and have seen the threat well in advance. These are some of the very few people on the planet who have a clue re: the phylogenetic aspect about the origins, how this variant has incubated for DECADES, what its mutation trigger agents may have been, and where it may have eventually spawned into the natural born killer it is, which is NOT a lab.
Through phylogenetic study it is now known that HIV originated not in 1979, or 1984 when it went mainstream, but a century earlier in 1884. - Unknown Known?
HIV aka AIDS, SIDA now known to have been killing a CENTURY earlier along with the participants in the Gunfight At The OK Corral. Bet you didn't see that one coming or this.. Our scientists methods and technology are not yet advanced enough to rapidly develop a cure or efficacious vaccine for HIV or COVID. It can take eons of mutation to come to fruition in Mother Nature's soup kitchen, so when I hear vaccine soon or now, I just shake my head and say serenity now.  As for the MSM second hand bat guano and the "five eyes Echelon" report, MSM sensationalized over speculation for the conspiracy theory minded, and those who are NOT in the know viz. misinformed and ignorant.  Remember, all lies lead to the truth, and now a word from our sponsors...

These BSC daze we just scuttle about with a Frankenbrau in hand mumbling like an insurance agent from Southie... R U covid? I got covid. If u not covid, ya bat shit crazy and needs to be covid. U should always be covid. Get covid now. The only way we roll is fully covid.  Those who want liberty, without responsibility should be gettin covid fast. Nobody should be allowed to roam the streets free without bean covid. I'm totally covid, R U covid?  Don't miss out on this once in a life time offer. Please run down to your friendly local branch Covidian Insurance agent and git fully covid now, before its too late.
And now we continue our in vivo triple bill from the Corona Theatre with the Not Ready For Pandemic Primetime Players presentation of... Covid Takes A Holiday? Mr. Covid Goes To Washington and A Covid Too Far?

Alex, lets try Philosophy for $2000. Trebek: Philosophers distinguish between 2 kinds of knowledge: a priori, by thinking, and this, from experience.  

We tire of the whole "it started in a lab" conspiracy theory and all the posturing and finger pointing, so let's set the record straight.  Starting with the Plague of Justinian, the 1st Plague Pandemic occurred in 541-544 AD and reoccurred in western Eurasia and North Africa over the next two centuries, but could have its genomic origins around 3800 BC. Contrary to original thought this plague travelled through the southern maritime roads of the Indian Ocean and entered the Red Sea before reaching Egypt.  The birthplace of the 1st Plague was between Xinjiang, China and Tian Shan, a system of mountain ranges on the borders of Kyrgyzstan, Kazakhstan, and China.

The 2nd Pandemic of recurring plagues was between the 13th and 18th centuries. This plague travelled the northern road of the Eurasian steppes and the southern maritime roads, stretching from South-east Asia to East Africa, the Middle East and Europe. The Black Death was only the 1st wave during the 2nd Pandemic in the years 1346-1353, but began several decades earlier near the Tibetan-Qinghai Plateau in China.


The 3rd Pandemic lasted roughly between 1860-1960, killing millions in South and East Asia at the turn of the 20th century, and began in the Chinese province of Yunan around 1855. Empirically based phylogenetic studies tie all three plagues to the same genome  found in the Tibetan-Qinghai Plateau, an area spanning from central China to Eastern Tajikistan, bordered in the north by the Eurasian steppes of Mongolia. Does one sense a theme, pattern or long term trend which does not involve conspiracy theory or other second hand bat guano?


Answering Trebek's 4th query: What is Empirical or A Posteriori?

Case in point, the Tian Shan are separated from the Tibetan Plateau by the Taklimakan Desert and the Tarim Basin to the south. The high altitude mountainous Tian Shan and Tibetan plateaus are historic reservoirs for bacteria, viruses, crossed by nomadic peoples migratory paths and trade routes. Moving West, for our purposes the 2nd Plague Pandemic is of particular interest.  Early outbreaks wiped out 60% of the population whereas later outbreaks were less devastating, only killing 10-20% of the population with each recurrence. Point in fact, medieval and Early Modern people grew accustomed to the plague, and took this periodic loss of population or culling of the herd in stride.


On that note, we come full circle in our apropos theme and title, we think. Bats are essential pollinators which eat fruit, nectar, and pollen as well as insects often found around such. i.e. mosquitoes, leafhoppers, beetles, rootworm larva, moths, grasshoppers, scorpions, centipedes, ants, flies, and crickets.  
Bats are also a natural animal reservoir of deadly viruses, human and otherwise where viral recombination can occur. One need not import from spies or leak from labs, what has been cooking all along, and can be found in a flying pollinator species that is everywhere on the planet except the Arctic, Antarctic and a few isolated Oceanic islands.  Nobody needs to get bit by a pangolin, civet or bat nor eat one. Just sample a not quite clean apple, banana, fruit, nectar, pollen etc. upon which a carrier bat has shed a transmittable virus through contact, saliva, urine or feces.  And even that transmission vector may be unnecessary...
There are an estimated 1031 viruses on Earth... the vast majority of which remain unidentified and uncharacterized. - Out Of The Blue?
Roughly 20 years ago we began finding genetically similar viruses occurring in very different environments around the globe. - Dr. Curtis Suttle
Each day, it is calculated, some 800 million viruses cascade onto every square meter of the planet. Bacteria and viruses are swept up in the atmosphere in small particles from soil-dust and sea spray.  How much of that material is carried up above the atmospheric boundary layer above 2,500 to 3,000 metres? At that altitude, particles are subject to long range transport unlike particles lower in the atmosphere. In Spain's Sierra Nevada Mountains, researchers found billions of viruses and tens of millions of bacteria are being deposited per square metre per day. The deposition rates for viruses were nine to 461 times greater than the rates for bacteria. Speaking of peaks, imagine what can be found at the 4500 metre Tibetan Plateau and the 7400 metre Tian Shan. Nattering another day.  Yup, COVID19 came from China, so what, doesn't everything, especially things that go viral?  Rimshot.... don't forget, I'm here all week folks.
And a voice was screaming: "Holy Jesus! What are these goddamn animals?"... No point mentioning those bats, I thought. The poor bastard will see them soon enough.... The car suddenly veered off the road and we came to a sliding halt in the gravel. I was hurled against the dashboard.  My attorney was slumped over the wheel. “What’s wrong?” I yelled. “We can’t stop here. This is bat country!" Hunter S. Thompson
On that Gonzo note, times are a changin... in public people used to cough to cover up a fart, now they fart to cover up the cough. What no theme song this week?  Pipe down baby ducks, in keeping with our theme please make do with some modified lyrics from two weeks ago... 
My, my, hey, hey Covid19 is here to stay, Hey, hey, my, my Covid19 can never die, there's more to the picture than meets the eye... out of the blue and into the black. You pay for this but they give you that, and once your gone you can't come back. Hey, hey, my oh my"
In closing out tonight's theme, in any sense of the word, "peak" can be presumptive, our forecast?  Near term or interim single stranded positive sense rna peaks, with possible scattered mutations and variant thundershowers. Up in our next segment, Sports of yesteryear, but first, how to tell what time it is...

If you did not watch the video, you will be just as clueless as the ADD Twitter afflicted. 
Answering Trebek's original query: What are bells hanging in a belfry... located in a distinct place within Italian architecture, the Campanile, and when inactive for an extended period of time, a home to bats. 

Be well, more to come in COVID19: The Prisoner? Stay tuned, no flippin.

Recommended Reading:
COVID19: Corona Virus Series
Timeline of Plague
A Tale of Plagues

Comments

Salmo Trutta said…
The predisposed have a low VO2 max.